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M. Shaaban, A., M. Ibrahim, H., H. Mohamed, A. (2019). Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice. Egyptian Journal of Aquatic Biology and Fisheries, 23(4), 391-408. doi: 10.21608/ejabf.2019.56733
Amal M. Shaaban; Hany M. Ibrahim; Azza H. Mohamed. "Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice". Egyptian Journal of Aquatic Biology and Fisheries, 23, 4, 2019, 391-408. doi: 10.21608/ejabf.2019.56733
M. Shaaban, A., M. Ibrahim, H., H. Mohamed, A. (2019). 'Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice', Egyptian Journal of Aquatic Biology and Fisheries, 23(4), pp. 391-408. doi: 10.21608/ejabf.2019.56733
M. Shaaban, A., M. Ibrahim, H., H. Mohamed, A. Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice. Egyptian Journal of Aquatic Biology and Fisheries, 2019; 23(4): 391-408. doi: 10.21608/ejabf.2019.56733

Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Article 31, Volume 23, Issue 4, October 2019, Page 391-408  XML PDF (976.02 K)
Document Type: Original Article
DOI: 10.21608/ejabf.2019.56733
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Authors
Amal M. Shaaban; Hany M. Ibrahim; Azza H. Mohamed
Abstract
The present study is designed to evaluate the therapeutic effect of Crocus sativus(saffron) aqueous extract (CSE) alone or in combination with praziquantel on Schistosoma mansoni infected mice. Parasitological, immunological, pathological and immunohistochemical parameters and surface topography of worms were determined. Treatment of S. mansoni infected mice with saffron or PZQ revealed a significant reduction in worm burden, hepatic and intestinal ova count with a decline in granuloma diameter. There was an increase in total IgG and IL-10 blood levels after treatment with PZQ and/or CSE. Superoxide dismutase (SOD) and catalase levels were improved in infected mice treated with CSE in comparison with infected mice. Male worm surface ultrastructure examination showed a swelling, rupture of numerous tubercles with marked decrease in spines and severe peeling of tegumental dorsal surfaces after treatment with saffron. In conclusion, the administration of aqueous extract of Crocus sativus is effective treatment for S. mansoni infection.
Keywords
Crocus sativus; Schistosoma mansoni; Saffron; Granuloma; antioxidants; Worm SEM
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