et al., A. (2025). Utilization of Shark Cartilage Byproducts from Fisheries for Anti-Inflammatory Biomedical Applications in LPS-Induced Mice. Egyptian Journal of Aquatic Biology and Fisheries, 29(4), 835-849. doi: 10.21608/ejabf.2025.442288
Agustin et al.. "Utilization of Shark Cartilage Byproducts from Fisheries for Anti-Inflammatory Biomedical Applications in LPS-Induced Mice". Egyptian Journal of Aquatic Biology and Fisheries, 29, 4, 2025, 835-849. doi: 10.21608/ejabf.2025.442288
et al., A. (2025). 'Utilization of Shark Cartilage Byproducts from Fisheries for Anti-Inflammatory Biomedical Applications in LPS-Induced Mice', Egyptian Journal of Aquatic Biology and Fisheries, 29(4), pp. 835-849. doi: 10.21608/ejabf.2025.442288
et al., A. Utilization of Shark Cartilage Byproducts from Fisheries for Anti-Inflammatory Biomedical Applications in LPS-Induced Mice. Egyptian Journal of Aquatic Biology and Fisheries, 2025; 29(4): 835-849. doi: 10.21608/ejabf.2025.442288
Utilization of Shark Cartilage Byproducts from Fisheries for Anti-Inflammatory Biomedical Applications in LPS-Induced Mice
The utilization of marine byproducts, such as shark cartilage, presents a sustainable strategy for the development of novel biomedical applications. This study investigated the anti-inflammatory potential of shark cartilage extract derived from Prionace glauca, a byproduct of fisheries, in a lipopolysaccharide (LPS)-induced mouse model of inflammation. The cartilage was processed via maceration in distilled water (1:10 b/v) at 45°C for 8 hours, and its chondroitin sulfate (CS) content was quantified using High-Performance Liquid Chromatography (HPLC), yielding an average of 2.23%. Male BALB/c mice were assigned to seven groups, including an LPS-only group, a standard CS group, a commercial supplement group (Welmove), and three dosage groups of shark cartilage extract (50, 100, and 200%). Inflammation was induced through intraperitoneal injection of LPS (1mg/ 100mL PBS), and immune responses were assessed by analyzing TNF-α and IFN-γ expression in CD4+ T cells and NK cells via flow cytometry. The extract significantly reduced the percentages of CD4⁺TNF-α⁺, CD4⁺IFN-γ⁺, and NK⁺IFN-γ⁺ cells in a dose-dependent manner (P < 0.05), with higher doses (D2 and D3) restoring cytokine expression toward baseline levels. These findings highlight the potential of shark cartilage byproducts as a valuable source of natural anti-inflammatory agents, supporting their further development in pharmaceutical and biomedical fields.
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