Ahmed et al., S. (2023). Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model. Egyptian Journal of Aquatic Biology and Fisheries, 27(6), 1131-1140. doi: 10.21608/ejabf.2023.334657
Saleem Ahmed et al.. "Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model". Egyptian Journal of Aquatic Biology and Fisheries, 27, 6, 2023, 1131-1140. doi: 10.21608/ejabf.2023.334657
Ahmed et al., S. (2023). 'Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model', Egyptian Journal of Aquatic Biology and Fisheries, 27(6), pp. 1131-1140. doi: 10.21608/ejabf.2023.334657
Ahmed et al., S. Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model. Egyptian Journal of Aquatic Biology and Fisheries, 2023; 27(6): 1131-1140. doi: 10.21608/ejabf.2023.334657
Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model
Erythrina variegate (EV) possesses a wide range of biological activities, including-anticancer,-antidiabetic, hepatoprotective, -antirheumatic, antibacterial, and antiviral properties. Methanolic extract of Erythrina variegate (MetEEV) has not been studied for its neuroprotective properties. The purpose of this study was to look into the effect of MetEEV-on-scopolamine (Sco)-induced anxiety, amnesia, and brain oxidative stress in zebrafish, in addition to figuring out the underlying mechanism. The zebrafish were given MetEEV (260, 520, and 780g/ L) for seven days in a row before being given Sco (100μM) for 30 minutes before the behavioral tests (locomotor activity and cognitive function). The in-vivo antioxidant status and Acetylcholinesterase- (AChE) -activity were also -evaluated for the further assessment of possible mechanisms of MetEEV in enhancing memory capacities in zebrafish. MetEEV-could-improve-memory-and-reduce-brain oxidative stress in sco-induced zebrafish, as well as regulating cholinergic function by inhibiting AChE activity. Our findings suggest that MetEEV could be a promising candidate compound for treating amnesia by restoring cholinergic activity and alleviating brain oxidative stress.
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