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Putra et al., R. (2022). Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish. Egyptian Journal of Aquatic Biology and Fisheries, 26(4), 623-635. doi: 10.21608/ejabf.2022.253136
Renanda B. D. S. Putra et al.. "Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish". Egyptian Journal of Aquatic Biology and Fisheries, 26, 4, 2022, 623-635. doi: 10.21608/ejabf.2022.253136
Putra et al., R. (2022). 'Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish', Egyptian Journal of Aquatic Biology and Fisheries, 26(4), pp. 623-635. doi: 10.21608/ejabf.2022.253136
Putra et al., R. Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish. Egyptian Journal of Aquatic Biology and Fisheries, 2022; 26(4): 623-635. doi: 10.21608/ejabf.2022.253136

Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish

Article 37, Volume 26, Issue 4, July and August 2022, Page 623-635  XML PDF (1006.2 K)
Document Type: Original Article
DOI: 10.21608/ejabf.2022.253136
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Author
Renanda B. D. S. Putra et al.
Abstract
In this research, acute toxicity (LC50) of cinnamaldehyde and its effect on hematology profile, as well as gill histology, in zebrafish were conducted. Briefly, 4-5 cm zebrafish were exposed to the following cinnamaldehyde concentrations: 0; 1.8; 2.4; 3.2; 4.2; 6.5; or 8.7 ppm for 96 hours. The results showed that cinnamaldehyde affected the hematology of zebrafish by increasing significantly the micronuclei and blood glucose at a concentration of 8,7 ppm (21 cells/mm3 and 193 mg/dL, respectively). Interestingly, the total leukocyte and the phagocytosis increased significantly at the concentration of 4.2 ppm of cinnamaldehyde.. Furthermore, cinnamaldehyde promotes edema, and hyperplasia in the gill structure tissue was observed at the concentrations 4.2, 6.5, and 8.7 ppm with total damage around 1%, 11%, and 45%, respectively. Cinnamaldehyde has acute toxicity LC50 at concentration 7.2 ppm and up to that certain concentration promotes tissue health in the aquatic organism.
Keywords
Cinnamaldehyde; Acute toxicity (LC50); Zebrafish; Hematology; Histology
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